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The precursor is proteolytically cleaved at a furin site to yield a highly glycosylated extracellular -subunit and a transmembrane -subunit, which are linked together by a disulfide bridge

To date, ~20 genetic mutations have been associated with PD, including missense mutations in SNCA (-syn), PARK7, and LRRK2 and missense mutations or loss-of-function mutations in PINK1, PRKN, PLOG, and GBA

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