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10.1016/j.cellsig.2022.110436 12 ChenM.ZhongW.XuW

Ann Emerg Med 1984

ESCs treated with glycolysis inhibitors or PDH blockers exhibit reduced histone acetylation and spontaneously differentiate, underscoring the importance of glycolysis-derived acetyl-CoA in maintaining an open chromatin, hyperacetylated state that supports pluripotency 24,25