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Appendices Appendix 1: Literature Search Strategies Literature Search - Vitamin B12 Economic Evidence-Based Analysis Search date: June 3, 2013 Databases searched: OVID MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, EMBASE

Major insurers might cover these treatments once medical necessity is established with appropriate documentation

If nausea persists, trying pre-bed dosing is an option, though this may slightly reduce efficacy by separating the peptide from morning cortisol elevation

5-Amino-1MQ has been examined in laboratory research studies as an inhibitor of NNMT, an enzyme associated with cellular metabolic pathways