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Epidemiol Rev (2001) 23(2):31342.10.1093/oxfordjournals.epirev.a000809 279 Lango AllenHEstradaKLettreGBerndtSIWeedonMNRivadeneiraFet alHundreds of variants clustered in genomic loci and biological pathways affect human height

Indeed, Mao and colleagues (283) found that global KO mice, in contrast to conditional -cell ZnT8 KO mice, exhibited adipocyte hypertrophy due to lipid accumulation in all major white adipose depots (VAT and SAT), accumulation of lipids in the liver, and increased expression of genes related to fatty acid synthesis and uptake