foxo4-dri senolytic or senomorphic improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells Senotherapy for chronic lung disease

Blood lactate concentration was determined using the lactate oxidase method (Lactate Pro 2 LT-1730

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Anti-Inflammatory Properties The peptide exhibits strong anti-inflammatory effects, which can be crucial in managing chronic inflammatory conditions like arthritis and inflammatory bowel disease (IBD)

Notably, intravenous administration of 0.5 mg/kg PBGD mRNA formulated by lipid nanoparticles into Cynomolgus macaque achieved 40% and 90% increases in the activity and expression level of PBGD, respectively, in comparison to the phosphate buffered solution (PBS) treated animals [154]