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doi: 10.1016/j.numecd.2022.06.007 40

It exhibited its immunomodulatory effect by decreasing the expression levels of MyD88, TLR4, TRAF6, and p65 genes and increasing the expression levels of I-B gene, MyD88, TLR4, TRAF6, phosphorylation p65, and phosphorylation I-B proteins in TLR4- NF-B signaling pathway

NOS uncoupling has been observed in patients with endothelial dysfunction secondary to diabetes mellitus, hypercholesterolemia or essential hypertension [9-11] and may be present also in scleroderma patients in whom vascular abnormalities and endothelial cell injury are a widespread finding

Swollen lymph nodes usually occur as a result of infection from bacteria or viruses