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The strongest candidates are patients with documented poor sleep quality (especially inadequate slow-wave sleep), elevated or dysregulated cortisol, and co-existing metabolic markers such as insulin resistance, rising fasting glucose, low IGF-1, or visceral fat accumulation

There were significant associations of the A allele of rs112735431 with younger age, lower rate of hypertension, lower Fazekas scores, fewer sites of extracranial atherosclerosis, and elevated serum homocysteine levels