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The reaction time was defined by placing the mouse on the hot plate, and the time was recorded when the animal showed hind paw licking or jumping, and the 45 sec period was observed to avoid tissue damage

Shen LJ, He JL, Yang DH, Ding YB, Chen XM, Geng YQ, et al

Preparation for Incorporating Refreshed Data and Request for Information on Timing To Effectuate Routine Updates In the CY 2024 PFS proposed rule, we continued to encourage interested parties to provide feedback and suggestions to CMS that give an evidentiary basis to shape optimal PE data collection and methodological adjustments over time

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