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Description

The chloride is located in a hydrophobic pocket interacting with I131 C1, V127 C1 and W222 C

In these systems, nicotinamide adenine dinucleotide phosphate (NADPH) acts as a source of reducing equivalents through two flavoenzymes oxidoreductases: glutathione (GSH) reductase (GR, EC 1.8.1.7) and thioredoxin (Trx) reductase (TR, EC 1.8.1.9) 23