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A VD model is established in rats by permanent common carotid arteries (CCA) ligation, caused cerebral ischemia, reduced blood flow, cognitive impairment, and neuronal damage [27] Daily oral HupA (0.1 mg/kg) for 14 days restored hippocampal choline acetyltransferase activity and normalized superoxide dismutase (SOD), lipid peroxide, lactate, and glucose levels [49]

IGF-1 levels increase significantly but remain within safety thresholds, and no glycemic worsening occurs in type 2 diabetes patients at therapeutic doses

Acute soft tissue injuries often show dramatic improvement within 4 to 6 weeks, while chronic tendinopathies may require the full 8 to 12 week duration

IGF1 LR3s unique mix of direct IGF-1 receptor start, extended half-life, and enhanced uptake makes it very valuable for research focused on IGF-1 signaling mechanisms, sustained anabolic effects, and uses where predictable, controlled receptor start is desired