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Inclusion criteria Systematic reviews, meta-analyses, randomized controlled trials (RCTs), longitudinal observational studies No clinical signs or symptoms of dementia at onset of study Study must report onset of dementia, Alzheimer disease (AD), or cognitive decline as an outcome measure N 100 Observational period 2 years or longer Exclusion criteria Cross-sectional studies, case series, case reports Non-English studies Institutionalized subjects (inpatients) Outcomes of interest Onset of dementia or Alzheimer disease Change in cognitive function Question 2

The human brain is especially vulnerable to oxidative stress because it accounts for only 2% of body mass but consumes 20% of oxygen 14

10.1021/bi035064b Biochemistry 20 ChangH.-P.LiangW.-C.LyuR.-C.ChiM.-C.WangT.-F.SuK.-L.et al (2010)

1998;62(Pt 6):48190