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FIGURE 4 4.3 Mechanisms and consequences of mitochondrial ROS imbalance following rotator cuff injury Mitochondria are the primary source of reactive oxygen species (ROS) in skeletal muscle, and oxidative stress is significantly exacerbated after rotator cuff injury (Thankam et al., 2018)

In addition to infection and inflammation, burn patients are vulnerable to ROS-mediated damages, thus, utilization of antioxidants can provoke the healing process of such wounds

Based on the current level of evidence, other authors have also suggested the use of oral or topical glutathione as an adjunctive therapy for facial melanosis