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Metformin inhibits macrophage activation and decreases the release of pro-inflammatory cytokines, such as TNF and IL-6 (Huang et al., 2009)

10.1038/sj.cdd.4401187 198 LeeH

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Where CJC-1295/Ipamorelin works by elevating GH to drive IGF-1 production in the liver, IGF-1 LR3 acts directly at the muscle tissue level binding IGF-1 receptors on muscle cells to stimulate protein synthesis, satellite cell activation, and muscle hypertrophy independently of the GH axis