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Siemens DR, Heaton JP, Adams MA, Kawakami J, Graham CH: Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer

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These results suggest that the knowledge of the molecular mechanism causing the transition of physiologically normal and soluble proteins to toxic oligomers and insoluble fibrils is essential for the development of treatment strategies

TG1 treatment increased the level of autophagy in cells, its cytotoxicity can be abrogated by ferroptosis inhibitor, suggesting that ferroptosis played a crucial role in TG1-induced cytotoxicity [132]