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Again, Watterson points out that this ignores the effect of the intracellular cytoplasmic aqueous milieu in which these changes take place, and which has the same density and thermal energy as its protein solute [Web reference 6]

This lipid damage compromises cellular integrity, disrupts intracellular signaling, and triggers further systemic inflammation, locking the patient into a vicious, self-perpetuating cycle of chronic illness