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The authors further reported that administration of curcumin at a dose of 400 mg/kg reversed IUGR associated intestinal damage by activating the Nrf2 signaling pathway and stimulating antioxidant enzymes secretion (SOD and CAT), and phase II metabolic enzyme, NQO1 expression

To further validate that SPI1 affects ferroptosis through ACSL4, we constructed small interfering RNA sequences of ACSL4 and selected si-ACSL4 with higher knockdown efficiency for subsequent studies (Fig

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha