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For instance, pharmacological inhibitors of complex I not only deplete CoQ 10 H 2 but also impair ATP production, which activates AMP-activated protein kinase (AMPK) 108

This dual alteration attenuates mTOR activity, which in turn inhibits downstream protein synthesis mediated by eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (p70S6K)

This creates a paradox where the medication treating your symptoms may worsen the underlying magnesium deficiency contributing to the problem

REM sleep is an active stage of sleep occurring about 90 minutes into the sleep cycle, which includes rapid eye movements and brain activity similar to waking levels