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The 68 week ages male mice were used in this study

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It was concluded that it worked by inhibiting the release of inflammation causative agents, macrophage induction, and release of phospholipase, histamine, kinin, and fibrinolysin mediators

Plant Physiol 132:11491152 Guy CL, Carter JV (1984) Characterization of partially purified glutathione reductase from cold-hardened and non hardened spinach leaf tissue