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Given the presence of both mandatory major criteria (polyneuropathy and monoclonal plasma cell proliferative disorder), at least one other major criteria (sclerotic bone lesions), and at least one minor criteria (skin changes, extravascular volume overload, endocrinopathy), as well as other associations (vitamin B12 deficiency), the patient was diagnosed with POEMS syndrome

The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification

Vitamin B12 deficiency can lead to a range of symptoms, including fatigue, weakness, pallor, dizziness, tingling in the hands and feet, memory impairment and depression

A practical routine: Morning: Cleanser Copper peptide serum (GHK-Cu) Vitamin C + antioxidant Moisturizer + SPF Evening: Cleanser Nanoretinol (retinoid pathway activation) Moisturizer with ceramides Separating copper peptides (AM) from retinol (PM) avoids any theoretical interaction between copper ions and retinol stability, while ensuring both pathways are activated daily