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1107,1108 PINK1 activators such as MTK458 facilitate mitophagy, suggesting therapeutic avenues for PD

Through separate mechanisms, AMPK stimulates glucose uptake by phosphorylating TBC domain family member 1 (TBC1D1) and thioredoxin-interacting protein (TXNIP), which regulate the movement and surface expression of GLUT4 and GLUT1

[The Working Group noted that the antioxidant NAC reversed only a small fraction of the cytotoxicity, thus a secondary effect of ROS could not be excluded