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This effect was shared by L-arginine, with an opposite effect seen by L-NAME, thereby portraying NO-system involvement in the healing of duodenal and skin defects, duodenocutaneous fistula closing and reinstated sphincter functions

Response: We appreciate the commenter's recommendation regarding the APC assignment of CPT code 52597 (0421T) but we disagree that the clinical complexity and resource required for CPT code 52597 (0421T) is comparable to CPT code 55882

However, controlled combination studies with clear statistical endpoints are rare, so synergistic effects remain largely hypothetical at present