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doi: 10.3389/fnins.2021.680214

Bulletin of Experimental Biology and Medicine, 135(6), 574-577

The field progresses slowly, in part because aging is multifaceted and complicated, meaning many mechanisms are still not well understood and long-term harms may not be known

Key Recommendations DOACs are considered first-line therapy for: prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF) for whom anticoagulation is indicated