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Restricted ketogenic diet enhances the therapeutic action of n-butyldeoxynojirimycin towards brain GM2 accumulation in adult sandhoff disease mice

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Discussion The main findings of our study in swine are that while DM alone substantially impacts cardiac hemodynamics, with elevated cardiac pre- and afterload provoking elevated coronary blood flow at rest which compromises coronary flow reserve, but also maladaptive cardiac remodeling with diastolic, systolic, and mitochondrial dysfunction, the addition of CKD causes no or little additional compromise on these parameters

The growth hormone-insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders