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Significance of ferroptosis in glioblastoma Ferroptosis holds uniquely actionable relevance in glioblastoma due to its intersection with glioblastoma-specific metabolic dependencies, therapy resistance, and immunologic constraints that distinguish it starkly from its role in other tumor types

Blood 116(21):1399, 2010

Future advancements will likely depend on integrated design pipelines that combine high-resolution transcriptomics with artificial intelligence-driven sequence optimization, facilitating predictive modeling of off-target profiles and delivery efficacy