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Because OS directly promotes neurodegeneration in flies 26 and mice 16 , LLCs may be a missing link underlying observations that age-related increases in OS are exacerbated by disruption of circadian clocks 8,14 , and that clock mutations accelerate OS-induced neurodegeneration in aging flies 15 and mice 16

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6.2 Probiotics, prebiotics, synbiotics, and postbiotics Probiotics are live microorganisms that colonize the human and animal intestines, maintaining the balance of the hosts intestinal microbiota and exerting beneficial effects on the hosts health (Mazziotta et al., 2023)