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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

The cell needs PARP1 activation to protect genome integrity, yet too much activation can drain NAD+ pools

While the exact timeline varies for everyone, many individuals with a genuine B12 deficiency begin to experience noticeable improvements in their energy levels within a few days to a week after their first injection

And its even worse for people who dont inject on a daily basis: Vitamin B12 is water-soluble, so only a tiny bit is absorbed, and the rest is urinated out within hours