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As lung elasticity declines, the respiratory system becomes weaker, resulting in a reduction in vital capacity and arterial oxygen pressure (Sharma and Goodwin, 2006)

98 From in vitro and clinical studies, equol has similar actions to 17-estradiol by stimulating collagen, elastin and TIMP expression, while inhibiting elastase and MMPs

Activating mutations in SHP2 have been well characterized as oncogenic drivers in hematologic malignancies, including juvenile myelomonocytic leukemia (JMML) and subsets of acute myeloid leukemia (AML), and as germline mutations which underlie Noonan syndrome (NS) 16

These results reinforce the role of GCLC in regulating not only GSH synthesis but also mitochondrial integrity and cell viability under oxidative stress [34,35,36]