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Methods: This umbrella meta-analysis synthesizes evidence from 46 randomized trials ( n = 30,133) to evaluate dietary supplements targeting core PCOS pathways

SH: Investigation, Writing original draft, Writing review & editing

73 Dilp8/INSL3 derived from tumor tissue activates the Lgr3 receptor in the hypothalamus, which increases the expression of anorexigenic nucleobinding 1 and decreases the expression of the orexigenic neuropeptides short neuropeptide F (sNPF) and NPF, triggering cachexia-associated anorexia

In the returned search results, we screened the top ten hits (and references within) encompassing in vitro , in vivo , and epidemiological studies and selected the most relevant papers reporting on the relationship between ATZ exposure, estrogenic effect, and breast cancer ( Figure 1