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Expect one to three days of increased nausea, possibly some digestive changes , and maybe some fatigue

Conclusion: Certain combinations of common genetic variants in cholestasis-associated genes show an association with cholestatic enzyme profiles and may be causally involved in the development of previously unexplained cholestatic liver injury

Tirzepatide users commonly report that high-fat foods cause the worst nausea and bloating, because the slowed gastric emptying means fat sits in the stomach longer

10.1016/j.cmet.2021.12.004 74 SasakiK.BohnenbergerS.HayashiK.KunkelmannT.MuramatsuD.PhrakonkhamP.et al (2012a)