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By contrast, 2 g of LC per day for 6 months increased fat-free mass in centenarians (53)

doi: 10.3389/fendo.2020.00175 228 KhalidEChangJP

-Ketoglutarate (-KG), a TCA cycle intermediate, serves as an essential cofactor for TET and JmjC demethylases, facilitating DNA and histone demethylation [251]

Este fenmeno, llamado somatopausia , contribuye a cambios que todos conocemos: ms grasa visceral, menos masa muscular, peor recuperacin, menor densidad sea, calidad de sueo disminuida y reduccin del IGF-1 (el mediador anablico de la GH en tejidos perifricos)