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Building on these studies, co-culture of human macrophages with either tumor ascites [62] or cancer cells [63] induced co-expression of HMOX1 and CD163, increased FPN and decreased FTH expression in macrophages (Fig

The protein similarity somehow reflects the gene arrangement since PtGSTF1 and PtGSTF2 genes are present in tandem on chromosome 2, PtGSTF4 , 5, 6, and 7 genes cluster on the scaffold 36, whereas PtGSTF3 and PtGSTF8 are found at isolated loci on the chromosomes 14 and 17, respectively

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Inhibition of 25-OHC expression or treatment with Fer-1, a ferroptosis inhibitor, significantly suppressed ferroptosis and lipid peroxidation in IMS32 cells and alleviated neurological damage, indicating that 25-OHC may serve as a potential therapeutic target for ALS (Urano et al., 2025)