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It is characterized by sudden, severe facial pain that follows the path of the trigeminal nerve, which has three branches on each side of the face

doi: 10.1038/s41419-021-04137-1, 19

however, research suggests it arises from the interplay of multiple factors, including biological, psychological, and social-environmental influences ( Figure 1 )

Notably, astrocytes serve as metabolic lifelines for neurons through indirect vascular coupling, a process by which they transport glucose, oxygen, and functional mitochondria to energy-deprived neurons [13]