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Funding This study was supported by grants from The National Natural Science Funds (82074228, 81922070 and 81973286)

Endothelial dysfunction or death can precipitate various pathological conditions, including vascular barrier disruption and vasoconstrictive/vasodilatory dysfunction

However, this results in negative energy balance to the host and production of reactive oxygen species (ROS) that harms the healthy tissue but not the tumor cells, which have high ability to produce antioxidants through an intermediate metabolite from the lactate formation (NADPH NADP + H + ) (66)

Afterwards, serum was separated and kept at 80 C for biochemical estimation