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Intranasal administration, though less studied with Dihexa specifically, would theoretically provide the most direct CNS delivery with minimal systemic exposurepotentially requiring even less frequent dosing to maintain effective brain tissue concentrations

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De Ita JR, Castilla-Cortzar I, Aguirre GA et al (2015) Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome

Hepatocyte Growth Factor Levels in Liver and Blood, and Post-operative Liver Cell Proliferation in Patients with Benign and Malignant Liver Tumors after Partial Hepatectomy