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Toral M, Romero M, Rodriguez-Nogales A, Jimenez R, Robles-Vera I, Algieri F, Chueca-Porcuna N, Sanchez M, de la Visitacion N, Olivares M, Garcia F, Perez-Vizcaino F, Galvez J, Duarte J (2018) Lactobacillus fermentum improves tacrolimus-induced hypertension by restoring vascular redox state and improving eNOS coupling

High doses of IGF-1 administration typically results in hypoglycaemia despite the potent suppression of circulating insulin concentrations it triggers [134, 135, 158]

Lastly, it suppresses the Nrf2 signaling pathway, including Nrf2 and its downstream targets of heme oxygenase-1 (HO1), NAD(P)H quinone dehydrogenase 1 (NQO1), GCLM, and glutamate-cysteine ligase catalytic subunit (GCLC) [312]