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To date, 14 studies have investigated GSH, GSSG, GSH/GSSG and/or tGSH levels in the plasma of healthy adults (Andriollo-Sanchez et al., 2005, Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Kretzschmar et al., 1991, Maciejczyk et al., 2019, Michelet et al., 1995, Nuttall et al., 1998, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), with the majority using HPLC (N = 10, 71%) (Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Michelet et al., 1995, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), and the remaining using colorimetry (N = 2, 14%) (Kretzschmar et al., 1991, Maciejczyk et al., 2019), enzyme-rate essay (Nuttall et al., 1998) (N = 1, 7%), and spectrophotometry (N = 1, 7%) (Andriollo-Sanchez et al., 2005) (Table 3)

On the other hand, fibrosis may contribute to oxidative stress or both of them may be triggered by an independent mechanism

doi: 10.1001/archderm.140.3.365 189 ShneydermanMAhlawatSChristopher-StineLPaikJJ

As an inducer of ferroptosis, inhibiting CHAC1-induced cell death may also hold therapeutic relevance for conditions like neurodegenerative diseases