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Seek urgent medical attention if you experience severe abdominal pain, jaundice, signs of dehydration, or difficulty breathing, as these may indicate serious adverse effects such as pancreatitis or gallbladder disease

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261 When IT therapies are combined with ICIs, systemic immune-related adverse events (irAEs), such as hepatitis, pneumonitis, or thyroiditis, may occur, highlighting the need for adaptive dosing, step-up schedules, and close clinical monitoring

Of note, NAC has been used adjunctively with various pharmacotherapies, particularly SSRI medication, without negative interactions and appears to show benefit in some treatment refractory patients