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Cancer Res 55:44654470 Yang W, Shen Y, Wei J, Liu F (2015) MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species

Oxidative Imbalance and Reduced GR Function Several specific scenarios create conditions where hydrogen water's mechanism may provide advantages over relying solely on GR-mediated glutathione recycling: NADPH deficiency states : Conditions that compromise NADPH production, such as glucose-6-phosphate dehydrogenase deficiency, metformin therapy, or severe caloric restriction, limit GR function due to insufficient cofactor availability

Among them, glutathione is often called the master defender because it helps clear harmful free radicals before they damage cells

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