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In this study, the impact of the PPAR agonist GW501516 on endothelial nitric oxide synthase (eNOS) uncoupling was investigated in BH-deficient hph-1 mice

10.1016/j.bbi.2003.12.009 204

Conversely, in large controlled clinical trials involving patients with moderate to severe stable COPD, the combination of fluticasone furoate/vilanterol enhanced lung function, reduced respiratory symptoms, and decreased the number of COPD exacerbations, including hospitalizations related to COPD [23]