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One of the most promising is Survodutide (BI 456906), a peptide currently in late-stage clinical trials

This mechanism dramatically boosts intracellular uptake-explaining the higher bioavailability of liposomal glutathione seen in clinical studies

In contrast, it showed a higher glutamate level in the brain in a mouse model of Parkinsons disease [141]

In contrast, spontaneous calcium spikes in astrocytes do not trigger a similar response, suggesting that astrocytic metabolism is mainly focused on meeting high metabolic demands of neurons (104, 105)