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USA 108 , 143148 (2011)

Implementing biomarkers such as serum or CSF levels of copper-binding proteins (such as ceruloplasmin, ATP7B and SOD1) and expression profiles of cuproptosis-related genes (such as FDX1, DLAT and LIAS) will enable clinicians to assess the efficacy of copper modulation strategies and optimize treatment protocols for individual patients (8,279,281)

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It is generally accepted that a horse that locks their patella (stifle joint), meaning the medial patellar ligament gets hooked over the medial trochlea of the femur, improve with conditioning or fitness training