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Under physiological conditions, Ca 2+ is predominantly stored in the ER, with cytosolic Ca 2+ levels approximately 10,000 times lower than those in the extracellular fluid (42)

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Clinical Update 6/13/2014 Vitamin D and Rheumatoid Arthritis A recent study shows that people with rheumatoid arthritis tend to have significantly lower levels of vitamin D in their blood than healthy individuals of the same age, gender and body weight

It depends on what you mean by targeted. For gut-focused support, capsules may feel more targeted because they pass through the digestive tract