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405 Most patients with severe thalassemia experience complications of iron overload due to blood transfusions, which promote oxidative damage to various organs, leading to endocrine and ultimately organ dysfunction

Users who began protocols in their forties or fifties and continued cycling for years describe maintaining physical and cognitive function that their peers have lost

Iron: Patients with iron deficiency anemia are often accompanied by a decrease in glutathione peroxidase activity

Study exclusion criteria may have selected patients at lower risk of overdose, and substantial loss to follow-up (approximately 80%) also may have biased estimates