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2,3 Stand-alone APAP is not the only drug formulation that should be suspected in potential APAP toxicity, however

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In addition, p53 induces GSH production by P21 (also known as cell cycle protein-dependent kinase inhibitor 1A, CDKN1A), which in turn upregulates GPX4 thereby inhibiting ferroptosis (Tarangelo and Dixon, 2018

The successful application of combined oxygen and mechanical recanalization in other cerebral ischemic conditions further illustrates this principle