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The mechanisms that elucidate the hypocholesterolemic effect of PFAs could be linked to the diminished activity of enzymes that play a role in lipid metabolism, such as 3-hydroxy-3-methylglutaryl-CoA reductase (an enzyme related to cholesterol synthesis), cholesterol-7 hydroxylase, fatty acid synthase, and the pentose phosphate pathway (Abdelli et al

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