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Recent studies have shown that synthetic monoclonal antibodies specific for SLC1A5 (i.e., KM4008, KM4012, and KM4018) are an effective therapeutic option for suppressing glutamine-dependent growth of CRC cells, but their efficacy in other cancer cells remains unclear 88

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It has been shown that alveolar epithelial lining fluid of patients with ARDS is deficient in total GSH compared to normal subjects (107), and neutrophil-mediated oxidants release leads to GSH deficiency and lung cell injury (107)