However, it is important to emphasize that these results cannot be attributed to L-carnitine alone: the observed efficacy relies on a cream combining multiple actives (L-carnitine, licochalcone A, and decanediol) and on its use in conjunction with photodynamic therapy
Malfatti CR, Royes LF, Francescato L, Sanabria ER, Rubin MA, Cavalheiro EA, Mello CF (2003) Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+, K+ -ATPase activity in the rat striatum and cerebral cortex
After 12 weeks of twice-daily application over the entire face, evaluation by visiometry revealed a significant reduction in two skin-roughness parameters (R2 and R3) among the women in the L-carnitine group, reflecting a visible improvement in skin texture and a decrease in wrinkles compared with the placebo
In the abstract, the concluded that: "A lack of an increase in corin expression or activation can be postulated to be a possible important pathophysiological mechanism responsible for the natriuretic peptide paradox in dogs with CHF, and warrants further investigation." One possible uniquely valuable use for natriuretic peptides tests is if the dog is approaching heart failure (HF) without any symptoms