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An siRNA approach has also been applied to circulating angiogenic cells and showed that a 50% silencing of the GLA gene is enough to significantly impact their migration capacity [58] To shed light on the mechanism by which -Gal A deficiency leads to another commonly observed Fabry disease phenotype, namely neuronal dysfunction, Kaneski et al

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Apolipoprotein E Genetic Variants Apolipoprotein E (apoE), which has three isoforms (apoE2, apoE3, apoE4) coded for by three different gene alleles ( ApoE2 , ApoE3 , ApoE4 ), is a pleiotropic protein with several major roles among which are cholesterol transport and efflux of key molecules from brain to blood, one of which is A42 (205)

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