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The NycoPrep 1.15 was supplemented with bovine serum albumin (BSA), DTT, KCl, MgSO4 and buffer, which reduced the density of the solution to 1.139 g/ml

This concentration represents the most concentrated feeding solution (LD50/10), from which further dilutions were prepared to produce the more diluted treatment solutions (LD50/20, LD50/40)

These, overall, suggest that flavokavains A and B in some kava preparations deviate in abundance from the traditional kava preparations and may account for the purported hepatotoxicity risk associated with kava use

Monitoring levels through blood or urine tests can help prevent toxicity and guide appropriate dosing