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Therefore, we carried out untargeted metabolomics profiling in culture medium from SIRT3 overexpressed adipocytes and found higher level of LC and lower levels of acylcarnitines, which in turn orchestrate metabolic reprogramming and polarization in macrophages

doi: 10.1021/bi101373h

Indeed, excess sebum is one of the key factors in this condition, as it promotes the obstruction of pilosebaceous follicles and the proliferation of Cutibacterium acnes , a bacterium involved in the development of inflammatory lesions